このエントリーをはてなブックマークに追加
ID 48710
FullText URL
Author
Mizuguchi, Yuko
Yoshimoto, Masaaki
Abstract
We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At 1 hr after reperfusion from ischemia for 1 hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or 1 hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.
Keywords
Edema
Ischemia-reperfusion injury
Low-dose irradiation
Reactive oxygen species
Antioxidation function
Published Date
2007-11-21
Publication Title
Journal of Radiation Research
Volume
volume48
Issue
issue6
Publisher
Journal of Radiation Research Editorial Committee
Start Page
505
End Page
513
ISSN
0449-3060
NCID
AA00705792
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/jrr/48/6/48_6_505/_article
language
英語
Copyright Holders
Copyright © 2007 by Journal of Radiation Research Editorial Committee
File Version
publisher
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT