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ID 18871
Eprint ID
18871
FullText URL
Title Alternative
Experimental Studies on the Pathogenesis of Polyradiculoneuritis Ⅱ. The Feature of Interactions With Poliovirus
Author
Ando, Osamu
Abstract
Certain results were obtained to illustrate the possibility of inducing the radiculoneuritis in experimental polio infections in mice. (1) No remarkable inflammatory changes in the spinal root, ganglia, nerve and the sciatic nerve in the adult mice paralysed by intrathecal infection with poliovirus (Mahoney & Lansing strain), and no histological difference between two strains. (2) The previous repeated administration of poliovirus (Mahoney & Lansing strain) intrathecally in the dosis of PD(50) (10(-4), 10(-5)) and 10(-7) or intraperitoneally in the dosis of 10(-1) and the challenge of same virus in the dosis of 10(-2). 10(-4~-6) intrathecal route revealed the mice with paralysis and without visible paralysis. In both mice no detectable histological pictures of polyradiculoneuritis in the spinal root, ganglia, nerve and the sciatic nerve were seen. (3) The reproducible data would seem to indicate the discernible points that the polyradiculoneuritis with Guillain-Barre Syndrome is not affiliated in the major part to the primary affection or repeated inoculations of poliovirus of the neuroallergic basis of pathogenesis.
Published Date
1958-03-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue3
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1037
End Page
1083
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/3/70_3_1037/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma