JaLCDOI 10.18926/AMO/31502
FullText URL fulltext.pdf
Author Ohta, Yoshio|
Abstract <p>Vecuronium is hydrolyzed in the body to 3-deacetyl (ORG 7268), 17-deacetyl (ORG NC58), and 3, 17-bis-deacetyl (ORG 7402) derivatives. Interactions of vecuronium and these metabolites were studied in phrenic nerve-hemidiaphragm preparations of rats. As already reported, ORG 7268 had a potent neuromuscular blocking action, and ORG NC58 and ORG 7402 had a weak neuromuscular blocking action. As expected, ORG 7268 increased the degree of neuromuscular block by vecuronium. However, a low concentration (10 microM) of ORG NC58 and ORG 7402 reversed the block by vecuronium. At a high concentration (50 microM), ORG NC58 and ORG 7402 increased the degree of block by vecuronium. Although we do not have enough data to explain these paradoxical reversal of neuromuscular block at this moment, we postulate that these results reflect the interaction between &#34;slow&#34; and &#34;fast&#34; competitive antagonists. Regardless of the mechanism, it should be emphasized that the concentrations of ORG NC58 and ORG 7402 which are necessary to reverse the block are much lower than those which facilitate the block. It is conceivable that this paradoxical reversal of the block occurs in experimental and clinical situations. Therefore, in determining the neuromuscular blocking action of a compound, the &#34;antagonistic&#34; effect of its metabolites should also be considered.</p>
Keywords vecuronium neuromuscular trasmission drug interaction competitive inhibition muscle relaxant
Amo Type Article
Published Date 1985-12
Publication Title Acta Medica Okayama
Volume volume39
Issue issue6
Publisher Okayama University Medical School
Start Page 471
End Page 480
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2868610
Web of Sience KeyUT A1985AWT4000007
JaLCDOI 10.18926/AMO/30988
FullText URL fulltext.pdf
Author Yong, Huang| Jinqiu, Guo| Ohta, Yoshio|
Abstract <p>Since clinical document architecture (CDA) became an American National Standards Institute (ANSI)-approved health level seven (HL7) Standard, many countries have begun making an eff ort to make local standards conform to CDA. In order to make CDA compatible with the many diff erent local standards existing in diff erent countries, we designed a prototype model using HL7 CDA R2 with medical markup language (MML), a Japanese medical data exchange standard. Furthermore, a referral letter system based on this model was developed. Archetypes were used to express medical concepts in a formal manner and to make 2 diff erent standards work collaboratively. We share herein the experience gathered in designing and implementing a referral letter system based on HL7 CDA, Release 2 (CDA R2). We also outline the challenges encountered in our project and the opportunities to widen the scope of this approach to other clinical documents.</p>
Keywords health level seven clinical document architecture medical markup language archetype
Amo Type Original Article
Published Date 2008-02
Publication Title Acta Medica Okayama
Volume volume62
Issue issue1
Publisher Okayama University Medical School
Start Page 15
End Page 20
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3559
Web of Sience KeyUT 000253549500003
Author 太田 吉夫|
Published Date 2001-12-31
Publication Title 岡山医学会雑誌
Volume volume113
Issue issue3
Content Type Journal Article
Author 太田 吉夫|
Published Date 2006-01-04
Publication Title 岡山医学会雑誌
Volume volume117
Issue issue3
Content Type Journal Article
Author 太田 吉夫|
Published Date 1985-12-31
Publication Title
Content Type Thesis or Dissertation