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ID 19089
Eprint ID
19089
FullText URL
Thumnail 70_2541.pdf 305 KB
Title Alternative
Precipitate Formation by Metal Ions and Antibiotics, Particularly Tetracycline Substances
Author
Yabe, Yoshiro
Hayashi, Sei
Nakayama, Goro
Ohnishi, Hiroyuki
Abstract
Many investigators have reported on the influence of various metal ions on antibiotics. The direct evidence for binding of metal ions with antibiotics is, however, very rare. The authors happened to find the precipitate formation by Mg⁺⁺ ion and aureomycin, and studied this phenomenon on various sorts of metal ions and antibiotics. The results are summarized as follows: 1) A marked yellow precipitate was formed by 10⁻² 10⁻³ M Mg⁺⁺ and 10⁻³-10⁻⁴M aureomycin. 2) A yellow precipitate was formed by 10⁻³M Mn⁺⁺ and 10⁻³-10⁻⁴M aureomycin, and was also formed by 10⁻⁴M Mn⁺⁺ and 10⁻³M aureomycin. 3) Just, like aureomycin, terramycin formed a yellow precipitate in the presence of Mg⁺⁺ or Mn⁺⁺. The degree of precipitate formation was, however, very weak as compared with aureomycin. 4) The precipitate formation between Mg⁺⁺ and aureomycin appeared at the pHs over 6.5 and became more marked with the rise of pH. 5) The acid solution of the yellow precipitate formed by Mg⁺⁺ and aureomycin showed a strong antibacterial action.
Published Date
1958-07-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue7
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
2541
End Page
2545
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/7/70_7_2541/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma