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ID 17615
Eprint ID
17615
FullText URL
Thumnail 88_459.pdf 8.08 MB
Title Alternative
Studies on membrane architecture of blood corpusclesPart Ⅰ: Ultrastructural study of freeze-etched erythrocyte membranes
Author
Tada, Shinya
Abstract
To study the biomembrane architecture, the ultrastructural observation of erythrocyte membranes was performed using the freeze-etching method. Freeze-etched erythrocyte membranes of normal subjects showed the smooth surface with small particles, which were measured 84±23 A in diameter, 3928±182/μ(2) in density in the internal surface (I.S.) and 147±30 A, 643±159/μ(2) in the external surface (E.S.). As the comparative study, the erythrocyte membrane of the patients with autoimmune hemolytic anemia (AIHA), systemic lupus erythematosus (SLE), dyserythroblastic anemia, paroxysmal nocturnal hemoglobinuria (PNH) and ovalocytosis were also examined with the freeze-etching method. The erythrocytes showing the functional or morphological abnormalities were proved to have a various type of abnormal architectures in the membranes. In AIHA and PNH, the improvement of anemia was observed after the administration of steroid hormon or vitamin E and was in the good correlation with the normalization of the erythrocyte membrane architecture.
Published Date
1976-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume88
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
459
End Page
476
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/88/5-6/88_5-6_459/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma