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ID 57457
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Sumi, Tomonari Research Institute for Interdisciplinary Science and Department of Chemistry, Faculty of Science, Okayama University ORCID Kakenhi publons
Okumoto, Atsushi Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
Goto, Hitoshi Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
Sekino, Hideo Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
Abstract
A two-step subdiffusion behavior of lateral movement of transmembrane proteins in plasma membranes has been observed by using single-molecule experiments. A nested double-compartment model where large compartments are divided into several smaller ones has been proposed in order to explain this observation. These compartments are considered to be delimited by membrane-skeleton "fences" and membrane-protein "pickets" bound to the fences. We perform numerical simulations of a master equation using a simple two-dimensional lattice model to investigate the heterogeneous diffusion dynamics behavior of transmembrane proteins within plasma membranes. We show that the experimentally observed two-step subdiffusion process can be described using fence and picket models combined with decreased local diffusivity of transmembrane proteins in the vicinity of the pickets. This allows us to explain the two-step subdiffusion behavior without explicitly introducing nested double compartments.
Published Date
2017-10-19
Publication Title
Physical review. E.
Volume
volume96
Issue
issue4-1
Publisher
American Physical Society
Start Page
042410
ISSN
24700045
NCID
AA11558033
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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publisher
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DOI
Web of Science KeyUT
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isVersionOf https://doi.org/10.1103/PhysRevE.96.042410
Citation
Numerical calculation on a two-step subdiffusion behavior of lateral protein movement in plasma membranes Tomonari Sumi, Atsushi Okumoto, Hitoshi Goto, and Hideo Sekino Phys. Rev. E 96, 042410
Funder Name
Japan Society for the Promotion of Science