このエントリーをはてなブックマークに追加
ID 13665
Eprint ID
13665
FullText URL
Thumnail 109_35.pdf 2.52 MB
Title Alternative
Histopathological study on choroidal vasculature in spontaneously hypertensive rats 2. Changes in the choroid and retinal pigment epithelial cells in the late stage of hypertension in these rats
Author
Sakaguchi, Noriko
Abstract
The pathological changes in the choroid and the retinal pigment epithelium in spontaneously hypertensive rats (SHR) aged 42-117 weeks were observed by transmission electron microscopy. Wistar Kyoto rats (WKY) were also studied as normotensive controls. Some of the endothelial cells of the choroidal arterioles and capillaries were degenerated. Focal cytoplasmic necrosis of the arteriolar smooth muscle cells was seen. The choroid showed severe sclerotic changes, and the retinal pigment epithelium was degeneated with dilated basal infoldings and intracellular vacuoles. Long-term hypertension causes degeneration of the outer retinal layer due to the obstructive changes in the choroidal vasculature.
Keywords
高血圧
脈絡膜
網膜
病理
Note
原著
Published Date
1997-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume109
Issue
issue3-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
35
End Page
40
ISSN
00301558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/109/3-6/109_3-6_35/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
References
1) 坂口紀子:高血圧自然発症ラットにおける脈絡膜血管病変の組織学的研究.第1報,病変の進行過程について.日眼(1986)90,1423-1435.
2) 上野聡樹,塚本 勇:脈絡膜循環障害による網膜色素上皮細胞の形態学的変化.第1報,早期崩壊過程.日眼(1976)81,572-584.
3) 上野聡樹,原山憲治,塚原 勇:脈絡膜循環障害による網膜色素上皮細胞の形態学的変化.第2報,中期変性過程.日眼(1977)81,728-742.
4) 山本起義,加賀典雄,下野廣昭,三木耕一郎:脈絡膜微小循環障害による網膜病変.第2報,中期の変化.日眼(1982)86,779-788.
5) 松橋英昭:蛍光色素注入レーザー照射による実験的脈絡膜血管閉塞モデルの組織学的研究.日眼(1988)92,433-443.
6) Ashton N : The eye in malignant hypertension. Trans Am Acad Ophthalmol Oto-laryngol(1972) 76, 17-40.
7) Hayreh SS, Servias GE and Virdi PS : Fundus leisions in malignant hypertension. Ophthamol (1986) 93, 1383-1400.
8) 山上 潔:高血圧症における網脈絡膜循環障害に関するトレーサー実験.日眼(1980)84,705-720.
9) 吉本弘志:実験的腎性高血圧ラットにおける末期重症網脈絡の研究.日眼(1987)91,756-770.
10) Kishi S, Tso MOM and Hayreh SS : Fundus lesions in malignant hypertension. Arch Ophthalmol (1985) 103, 1189-1197.
11) Vracko R : Basal lamina layering in diabetes mellitus. diabetes (1974) 23, 94-104.
12) 藤本伸一:実験的高血圧における脈絡膜循環の研究.第2報,高血圧自然発症ラットの脈絡膜組織血流量.日眼(1986)90,1203-1210.
13) Ross R, Glomset JA, and Harker L : Response to injury and atherogenesis. Am J Pathol (1977) 86, 675-684.
14) Mishima H and Kondo K : Ultrastructure of age changes in basal infoldings of aged mouse retinal pigment epithelium. Exp Eye Res (1981) 33, 75-84.
15) Bok D and Young RW : Phagocytic properties of the retinal pigment epithelium ; in The Pigment Epithelium, Zinn and Mormor eds, Harvard Univ Press, Cambridge (1979), pp 148-174.
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma