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ID 42813
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Title Alternative
Histology of the brain of rabbits with chronic local cerebral anaphylaxis
Author
Sakai, Kunitsune
Abstract
The cow sera with phosphatid obtained from the cerebral gray matter, of cows were given in the ear vein of adult rabbits for 2cc per kg as antigen. As effective injection, 1cc per kg of diluted antigen, namely 4 and 6 times diluted solution of antigen was given every 4 days for 3-10 months in their ear vein. Thus the chronic local cerebral anaphylactic rabbits were made. And the motor area, frontal lobe, nucleus lenticularis, substantia nigra, Ammon's horn and pia mater were histologically researched. After repeated effective injections for a long time, the disappearance, disturbance of arrangement, atrophy, edematous degeneration, glial involvement and neuronophagia etc. of nerve cells, striking gliosis, disappearance and swelling of the sheath, hypertrophy of the wall of vessels, increase of wall cells, dilatation of lymphatic cavity surrounding the vessel adventitium, hypertrophy of pia mater and proliferation of connective tissue cells etc, were found. It would appear that, by repeating effective injections with diluted antigen for a longtime, the chronic local cerebral anaphylactic rabbits were made, and the histological findings of their brains were similar to those which were found in the brain of old idiopathic epilepsy.
Published Date
1955-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume67
Issue
issue2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
403
End Page
428
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/67/2/67_2_403/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma