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ID 14129
Eprint ID
14129
FullText URL
Thumnail 105_601.pdf 3.38 MB
Title Alternative
Studies of human bone marrow stromal cells in the aged Part 2. Effects of anticancer agents on the growing dynamics of bone marrow stromal cells in the aged and their ability to sustain normal hemopoiesis
Author
Deguchi, Seigo
Abstract
Prolonged marrow suppresson after chemotherapy with anticancer agents is often seen, especially in elderly patients. The effects of anticancer agents on the growing dynamics of bone marrow stromal cells (BMSC) in the aged and their ability to sustain the growth of normal hemopoietic progenitor cells (suppportability) were examined to investigate the cause of prolonged marrow suppression. Daunorubicin (DNR) suppressed either the proliferation of BMSC or the ability to sustain hemopoiesis as a function of its concentration. Cytosine arabinoside (ara-C) did not suppress growing dynamics or supportability. Methotrexate (MTX) suppressed supportability at higher concentrations, even though it barely suppressed growing dynamics. These results were similar to those from an investigation in younger volunteers. It should be noted that DNR suppresses BMSC function at standard clinical concentrations. However, antimetabolites, especially ara-C are considered comparatively safe drugs for elderly patients.
Keywords
Human marrow stromal cells
Aging
Chemotherapy
Growing dynamics
Ability to sustain hemopoiesis
Published Date
1993
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
601
End Page
610
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/5-6/105_5-6_601/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma