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ID 15850
Eprint ID
15850
FullText URL
Thumnail 100_47.pdf 640 KB
Title Alternative
Studies of lipid metabolism in cultured smooth muscle cells.Part II. Effect of antioxidants on fatty acid metabolism.
Author
Demiya, Michitaka
Abstract
The effects of antioxidants on the fatty acid composition of cultured aortic smooth muscle cells obtained from normal, hypercholesterolemic and aged rabbits were studied in vitro. α-Tocopherol and coenzyme Q(10) were used as antioxidants.Cell lipid extracts were separated into cholesterol ester (CE), triglyceride (TG) and phospholipid (PL) fractions by thin layer chromatography. The fractions were analyzed by gas-liquid chromatography for fatty acid composition. Upon addition of α-tocopherol, the proportion of oleate (18:1) increased and that of linoleate (18:2) decreased in the CE and TG fractions, but that of stearate (18:0) increased and those of linoleate and arachidonate (20:4) decreased in the PL fraction.These effects of α-tocopherol were most significant in HL-SMC, and almost no change in Aged-SMC was observed.Addition of coenzyme Q(10) resulted small changes in the fatty acid composition of the cultured cells and culture media.
Keywords
平滑筋細胞
脂肪酸分析
α-トコフェロール
コエンザイムQ(10)
抗酸化剤
Published Date
1988
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume100
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
47
End Page
55
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/100/1-2/100_1-2_47/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma