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ID 17717
Eprint ID
17717
FullText URL
Thumnail 83_579.pdf 593 KB
Title Alternative
EXPRIMENTAL AND CLINICAL STUDY ON THE HEMODIALYSIS (WITH SPECIAL REFERENCE TO THE DIALYSIS COMPLICATION)
Author
Kutomi, Katsumi
Abstract
This is an experimental and clinical study to investigate the mechanism of the Disequilibrium-Syndrome in hemodialysis from the point of biochemical changes of the body fluid and osmotic pressure. METHOD. Mongrel dogs were used for this study. Three hour hemodialysis using Kolff's single coil kidney was performed on uremic dogs, which had been nephrec tomized bilatelally and, clinically hemodialysis was performed on 40 patients with renal failure, since November 1967, to December 1970. Dialyzers used in the study were either Kolff-Twin-coil type or Kiil's type. Effort has been made in this study to investigate correlations of parameters followed to patient with or without Disequilibrium-Syndrome. 1. Dialyzer. 2. BUN-Dialisanse. 3. Time of dialysis. 4. Severity of patient. RESULT. 1. The level of Urea-N in lymph and serum, resumed to normal by the end of the first hour of dialysis, but those in cerebrospinal fluid decreased very slowly. There were notable changes of excretory gradient on Urea-N between blood and cerebrospinal fluid. 2. Biochemical changes of thoracic duct lymph during hemodialysis were very similar to those of serum. 3. There was slight change of osmotic pressure between serum and cerebrospinal fluid before and after dialysis. 4. None of patients developed Disequilibrium-Syndrome in case of BUN below 110mg/dl, within 3 hour of dialysis, and 30 % of BUN-dializanse. CONCLUSION. It was fond in this study that osmotic-gradient per se might be one, not all, of cause of Disequilibrium-Syndrome. However. in clinical practice, rapid alteratons of homeostasis seems to be related to this syndrome.
Published Date
1971-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume83
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
579
End Page
590
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/83/11-12/83_11-12_579/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma