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ID 18888
Eprint ID
18888
FullText URL
Title Alternative
Effects of γ-Amino-β-hydroxybutyric Acid (GABOB) on the function and metabolism of the Perfused Cat Brain
Author
Marukawa, Shoichi
Abstract
The perfusion of the cat brain was performed according to the method of Ikeda, H. who modified the method of Geiger, A.. Electrocorticogram, cerebral blood flow, and biochemical and pharmacological findings in the case of the administration of GABOB were obtained respectively by the use of the perfusion method, and then the correlation of each appearance waseinvestigated. 1). Electrocorticogram of perfused cat brain was supressed by administration of GABOB in all cases. 2). The rate of cerebral blood flow, oxygen and glucose consumption and the liberation of lactic acid were all increased by the same treatment. 3). The above mentioned changes were reversible, namely those turned to normal soon after the interruption of GABOB administration. 4). All reflexfunctions as conjunctival reflexes, corneal reflexes, pupillary reactions and pain sensations, and respiration rate, blood pressure, electrocardiogram had represented no remarkable change. Accordingly, any activating effects of GABOB on ehe function of the perfused cat brain was not observed in all experiments.
Published Date
1961-09-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume73
Issue
issue7-9
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
677
End Page
686
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/73/7-9/73_7-9_677/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma