Proceedings of Okayama Association for Laboratory Animal Science
Published by Okayama Association for Laboratory Animal Science

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分泌型免疫グロブリンA の腸内細菌への結合活性は 高脂肪食の摂取により弱まる

Tsuruta, Takeshi Graduate school of Environmental and Life Sciences, Okayama University
MUHOMAH, Teresia Aluoch Graduate school of Environmental and Life Sciences, Okayama University
Sonoyama, Kei Research Faculty of Agriculture, Hokkaido University
Nishino, Naoki Graduate school of Environmental and Life Sciences, Okayama University
Abstract
Secretory immunoglobulin A (SIgA) is predominant antibody secreted into the gut relating to maintain gut homeostasis. In the present study, we focused on the SIgA coating of gut bacteria as a mucosal immune response affecting the gut bacteria following a high-fat diet (HFD). This study newly showed that the level of SIgA coating of gut bacteria was significantly decreased in HFD-fed mice than normal-fat diet (NFD)-fed mice. Furthermore, we found that the relative abundances of gut bacteria were significantly negatively or positively correlated with the level of SIgA coating of gut bacteria in NFD-fed and HFD-fed mice. Our observations suggest that a decrease in the level of SIgA coating of the gut bacteria through a HFD might relate to HFD-induced changes in bacterial composition.
Note
記念講演要旨(Summary of Commemorational Lecture)