Proceedings of Okayama Association for Laboratory Animal Science
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Assessment of acetate on anti-obesity effect with experimental animal
Yamashita, Hiromi
Published Date
2014-04
Abstract
Acetate is an endogenous metabolite of fatty acid β-oxidation in the liver mitochondria under
starved condition. Orally administered acetate is readily absorbed in the blood stream and then taken
up by tissues and activates AMP-activated protein kinase (AMPK) by increasing the AMP/ATP ratio.
Administered acetate shows a marked reduction in lipid accumulation in the adipose tissue, protection
against accumulation of fat in the liver, and improves glucose tolerance. It decreases the transcripts of
the lipogenic genes in the liver, indicating an inhibition of lipogenesis in that organ. Furthermore,
acetate treatment shows a higher rate of oxygen consumption and a smaller size of lipid droplets in white
and brown adipose tissues. It is indicated that acetate taken up has a potential to prevent obesity and
obesity-linked type 2 diabetes.
Note
特別講演要旨 (Summary of Special Lecture)