Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School <Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)
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Permalink : http://ousar.lib.okayama-u.ac.jp/14789
IgE-mediated allergy and cigarette smoking enhance the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes and bronchial hyperresponsiveness in patients with atopic asthma
Hosaki, Yasuhiro
Iwagaki, Naofumi
Nagata, Takuya
Fujii, Makoto
Yokoi, Tadashi
Hamada, Masanori
Tanizaki, Yoshiro
Abstract
Influences of IgE-mediated allergy and cigarette smoking on pathophysiology, evaluated by bronchial hyperresponsiveness and the generation of LTB4 and LTC4, of asthma were examined in 69 patients with asthma sensitive to inhalant allergens such as house dust mite and Candida albicans.
1 . Bronchial byperresponsiveness was significantly higher in previous and current smokers of asthmatics than in never-smokers. 2 . The generation of leukotrienes 84 (LTB4) and C4 (LTC4) by leucocytes was significantly larger in patients with serum IgE over 350 IU/ml than in those with serum IgE less than 150 IU/ml (LTB4 : p
Keywords
lgE-mediated allergy
bronchial hyperresponsiveness
LTB4
LTC4
asthma
cigarette smoking
ISSN
1348-1258
NCID
AA11840279