Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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The generation of leukobienes B4 (LTB4) and C4 (LTC4) and bronchial hyperresponsiveness in patients with asthma and spa therapy

Hosaki, Yasuhiro
Tsugeno, Hirofumi
Okamoto, Makoto
Nishida, Norikazu
Yokoi, Tadashi
Tanizaki, Yoshiro
Abstract
Changes in the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes after spa therapy were examined in 30 patients with asthma. 1. The efficacy of spa therapy was marked in 8 (26.7%), and moderate in 16 (53.3%) of 30 patients with asthma, and slight or no efficacy of the therapy was observed in the residual 6 patients (20.0%). 2. Bronchial reactivity to methacholine was the highest in patients with slight or no efficacy of spa therapy, however. there were no significant differences among the three groups classified by clinical efficacy. 3. The generation of LTC4 was significantly higher in patients with slight or no efficacy compared with the generation in those with marked (p
Keywords
asthma
spa therapy
bronchial hyperresponsiveness
LTB4
LTC4
ISSN
0918-7839
NCID
AN10430852