REPO

Annual Reports of Misasa Medical Center, Okayama University volume72
2002-02-01 発行

The generation of leukobienes B4 (LTB4) and C4 (LTC4) and bronchial hyperresponsiveness in patients with asthma and spa therapy

Ashida, Kozo Kaken ID researchmap
Mitsunobu, Fumihiro Kaken ID publons researchmap
Hosaki, Yasuhiro
Tsugeno, Hirofumi
Okamoto, Makoto
Nishida, Norikazu
Takata, Shingo Kaken ID publons
Yokoi, Tadashi
Tanizaki, Yoshiro
Publication Date
2002-02-01
Abstract
Changes in the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes after spa therapy were examined in 30 patients with asthma. 1. The efficacy of spa therapy was marked in 8 (26.7%), and moderate in 16 (53.3%) of 30 patients with asthma, and slight or no efficacy of the therapy was observed in the residual 6 patients (20.0%). 2. Bronchial reactivity to methacholine was the highest in patients with slight or no efficacy of spa therapy, however. there were no significant differences among the three groups classified by clinical efficacy. 3. The generation of LTC4 was significantly higher in patients with slight or no efficacy compared with the generation in those with marked (p
Keywords
asthma
spa therapy
bronchial hyperresponsiveness
LTB4
LTC4
ISSN
0918-7839
NCID
AN10430852
NAID