Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Intranasal glucocorticoid therapy in asthmatic patients with mucosal abnormalities of sinonasal cavity

Mifune, Takashi
Hosaki, Yasuhiro
Yokota, Satoshi
Tsugeno, Hirofumi
Takeuchi, Kazuaki
Nawa, Yuichiro
Tanizaki, Yoshiro
Ochi, Koji
Harada, Hideo
Abstract
Bronchial asthma is often accompanied with allergic rhinitis or chronic sinusitis. Mucosal abnormalities of sinonasal cavity may influence lower respiratory responses in patients with asthma. We experienced a case of 72-year-old woman with asthma, who had dyspnea on exertion and a large volume of expectoration of more than 100mℓ a day. Furthermore she had nasal symptoms (nasal obstruction and rhinorrea) with prominent post-nasal discharge. Computed tomography (CT) scans of sinonasal cavity revealed marked thickness of nasal mucosa. Although her asthma symptoms such as wheezing and dyspnea improved by administration of bronchodialators, antiallergic agent, and beclomethason di isocyanate (BDI) accompanied with spa therapy after admission, the volume of expectoration revealed no decrease and her peak expiratory flow (PEF) didn't increase. The volume of expectoration and the PEF showed marked improvement after starting of intranasal glucocorticoid therapy. It is suggested from her clinical course that treatment with intranasal glucocorticoids is very important in asthmatic patients with mucosal abnormalities of sinonasal cavity.
Keywords
bronchial asthma (気管支喘息)
rhinitis (鼻炎)
intranasal steroid therapy (鼻腔内吸入ステロイド療法)
expectoration (喀痰排出)
peak expiratory flow (ピークフロー)
ISSN
0918-7839
NCID
AN10430852