Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Dietary supplementation with n-3 fatty acids in bronchial asthma correlated with the generation of LTB4 and LTC4

Mifune, Takashi
Hosaki, Yasuhiro
Yokota, Satoshi
Tsugeno, Hirofumi
Tanizaki, Yoshiro
Yamamoto, Junko
Tsuji, Takao
Abstract
In recent years, it has been noted that there is a close correlation between leukotrienes and late asthmatic reaction (LAR). In this study, effects of dietary supplementation with perilla seed oil rich in alpha-linolenic acid, which is speculated to affect the generation of leukotrienes through metabolism of arachidonic acid (AA), were evaluated in 6 patients with asthma. The symptoms and ventilatory function were improved after 2-week dietary supplementation with perilla seed oil. The generation of LTB4 and LTC4 by peripheral leucocytes stimulated with Ca ionophore A23187 was significantly suppressed by the dietary supplementation (LTB4 and LTC4 ; p<0.05). Regarding the composition of fatty acids in serum phospholipids, the concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and AA tended to increase after the supplementation, accompanied with an increase in the ratio of EPA to AA. These results suggest that dietary supplementation with perilla seed oil brings beneficial effects in the treatment of asthma.
Keywords
n-3系脂肪酸 (n-3 fatty acids)
気管支喘息 (bronchial asthma)
アラキドン酸 (arachidonic acid)
LTB4
LTC4
ISSN
0918-7839
NCID
AN10430852