Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Difference in small airway inflammation between type Ⅱ (bronchiolar obstruction) asthma and obstructive bronchiolitis

Mifune, Takashi
Hosaki, Yasuhiro
Yokota, Satoshi
Tsugeno, Hirofumi
Takeuchi, Kazuaki
Nawa, Yuichiro
Tanizaki, Yoshiro
Tada, Shinya
Harada, Mine
Abstract
Ventilatory function and inflammatory cells in airways were compared between patients with type Ⅱ (bronchiolar obstruction) asthma and those with obstructive bronchiolitis. 1. Age and age at onset were higher in patients with type Ⅱ asthma than in those with obstructive bronchiolitis. IgE-mediated allergic reaction was observed in patients with type Ⅱ asthma, but not in those with obstructive bronchiolitis. 2. In ventilatory function tests, all ventilatory parameters examined were lower in patients with type Ⅱ asthma compared to those with obstructive bronchiolitis, and the differences were significant in FEV1.0% (p<0.001), % MMF (p<0.02), and V50 (p<0.01). 3. The proportion of BAL neutrophils was very high in type Ⅱ asthma (55.7%) and obstructive bronchiolitis (74.4%), however, this was not significant. 4. Absolute numbers/BAL fluid of total cells, BAL macrophages and BAL neutrophils were significantly higher in patients with obstructive bronchiolitis than in those with type Ⅱ asthma. 5. The results on absolute number/mℓ of BAL cells demonstrated that number of BAL neutrophils markedly larger in patients with obstructive bronchiolitis compared to those with type Ⅱ asthma. These results show that high proportion of BAL neutrophils was observed in the two respiratory diseases, however, the degree of inflammation in airways was markedly greater in obstructive bronchiolitis.
Keywords
Ⅱ型喘息 (Type Ⅱasthma)
閉塞性細気管支炎 (Obstructive bronchiolitis)
換気機能 (Ventilatory function)
BAL好中球 (BAL neutrophiIs)
IgE系反応 (IgE-mediated allergy)
ISSN
0918-7839
NCID
AN10430852