REPO

Annual Reports of Misasa Medical Center, Okayama University volume63
1992-06 発行

抗原および抗ヒトIgEに対する抗塩基球の反応性. 3.Ca2(+)の細胞内流入およびヒスタミン遊離

Tanizaki, Yoshiro
Kitani, Hikaru
Okazaki, Morihiro
Mifune, Takashi
Mitsunobu, Fumihiro Kaken ID publons researchmap
Kimura, Ikuro
Publication Date
1992-06
Abstract
The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE.
Keywords
Ca(2+) influx (Ca2+流入)
histamine release (ヒスタミン遊離)
house dust (ハウスダスト)
Candida albicans (カンジダ)
anti-lgE (抗ヒトIgE)
ISSN
0913-3771
NCID
AN10430852
NAID