Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Antiallergic agent, azelastine, inhibits (45)Ca uptake and histamine release in rat mast cells stimulated by antigen

Tanizaki, Yoshiro
Ohtani, Jun
Kimura, Ikuro
Abstract
The effect of antiallergic agent, azelastine, was examined in immunogical secretory process of mast cells. 1. Azelastine significantly inhibited (45)Ca uptake by mast cells stimulated by antigen, and the maximum inhibition was attained at a concentration of 50 μg/ml showing approximately 30.5 % inhibition. 2. Azelastine also inhibite the release of histamine from mast cells by antigen. The maximal inhibitory rate was 38.1%. The effect of azelastine on (45)Ca uptake and histamine release was dose-dependent, and compatible at employed cocentration of the agent. 3. Tachpylaxis to azelastine was not found in this experimental system.
Keywords
Azelastine (アゼラスチン)
Rat mast cells (ラット肥満細胞)
(45)Ca uptake (Ca(2+)uptake)
Histamine release (ヒスタミン遊離)
ISSN
0913-3771
NCID
AN10430852