Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Bronchial asthma in the elderly. Relationship to allergic reaction and airway inflammation

Tanizaki, Yoshiro
Kitani, Hikaru
Okazaki, Morihiro
Mifune, Takashi
Tanimizu, Masakuni
Honke, Naoko
Kusaura, Yasuhiro
Ochi, Koji
Harada, Hideo
Kimura, Ikuro
Abstract
Clinical features of bronchial asthma in the elderly were analyzed by observlng IgE-mediated allerglc reactions evaluated by immediate skin reaction and specific IgE antibodies to allergens, ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. The frequency of positive immediate skin reaction and positive RAST score to allergens was in general low in the elderly patients over age 70. 2. Ventilatory function was widely variegated, and fifteen cases (60%) of the 25 Subjects showed considerably high values of FEV(l.0%), % PEFR, % MMF, % V(50) and % V(25), and the mean value of FEV(1.0%) in these cases was 71.3%. 3. The decreased value of % V(25) was related to BAL neutrophilia in 2 cases, but any correlation was not found between BAL neutrophilia and decreased value of % V(25) in 9 csese of the eleven subjects who had the BAL examination. The results show that in asthma of elderly patients, IgE-mediated allergic reactions are weak, and that a decreased value of % V(25) can be observed without BAL neutrophilia.
Keywords
elderly subjects (老年者)
lgE-mediated allergic reaction (IgE系反応)
ventilatory function (換気機能)
BAL neutrophilia (BAL好中球)
bronchial asthma (気管支喘息)
ISSN
0913-3771
NCID
AN10430852