Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Basophil reactivity to anti-IgE and calcium ionophore A23187 in patients with bronchial asthma

Tanizaki, Yoshiro
Sudo, Michiyasu
Kitani, Hikaru
Kawauchi, Kazuhisa
Mifune, Takashi
Okuda, Hiroyuki
Komagoe, Haruki
Tada, Shinya
Kimura, Ikuro
Abstract
The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions.
Keywords
Histamine release (ヒスタミン遊離)
Basophils (好塩基球)
Anti-lgE (抗ヒトIgE)
Calcium ionophore A 23187 (カルシウムイオノフォァA23187)
Bronchial asthma (気管支喘息)
ISSN
0913-3771
NCID
AN10084718