Journal of Okayama Medical Association
Published by Okayama Medical Association

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アレルギーにおけるheparinの役割に関する研究 第1編 即時型アレルギー反応におけるheparinの作用機序に関する研究

Ono, Hatsuko
99_537.pdf 1.14 MB
Abstract
The action of heparin on allergic reactions was examined in skin and bronchial reactions to chemical mediators, in the rat PCA reaction and antigen-induced degranulation of rat peritoneal mast cells. Heparin inhibited the histamine-induced skin reaction in rats. Bronchoconstriction caused by histamine and acetylcholine was also inhibited by pre-treatment with heparin. The skin reaction due to reaginic antibody (PCA), but not that due to precipitated antibody, in rats was inhibited by heparin administration. Heparin moderately inhibited the degranulation of rat peritoneal mast cells elicited by reaginic antibody, but the inhibitory action was not as strong as that of prednisolone or disodiumcromoglycate.
Keywords
heparin
reagin様抗体
皮内反応
化学伝達物質
肥満細胞
ISSN
0030-1558
NCID
AN00032489