Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

モノクローナル抗体を用いた肺癌組織浸潤リンパ球の研究

Watanabe, Tetsuya
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Abstract
Subsets of the infiltrating lymphocytes in lung cancer tissues of 64 patients were identified by immunohistochemical staining (ABC method) using monoclonal antibodies (Leu 2a, Leu 3a+b, Leu 4, Leu 7 and Leu 14). T cells were predominant in lung cencer tissues, and tended to infiltrate into cancer cell nests and stoma, diffusely and focally. On the contrary, B cells in most cases were observed to infiltrate focally apart from cancer cells. There was a significant reverse correlation between the intensity of the T cell infiltration and the tumor T factors, and also between Th/i cell infiltration and the tumor T factors. Th/i cells were more prominent in lung cancer than Ts/c cells, and Ts/c cells scarcely infiltrated. NK, K cells also infiltrated scarcely and sparsely, and there was no correlation between the intensity of NK, K infiltration and the clinical condition. It was concluded that immunohistochemical examination of infiltrating lymphocyte subsets in lung cancer can reveal direct local immune responses and may be a useful method for making prognoses.
Keywords
モノクローナル抗体
リンパ球サブセット
肺癌
肺癌浸潤リンパ球
免疫組織化学
ISSN
0030-1558
NCID
AN00032489