Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

ヒト肺癌実験モデルの作製に関する研究 第1編 ヒト肺扁平上皮癌細胞株(EBC-1株)およびヒト肺腺癌細胞株(ABC-1株)の樹立とその性状

Watanabe, Yoichi
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Abstract
Two human lung cancer cell lines designated as EBC-1 and ABC-1 were newly established for the purpose of making an in vitro experimental model of human lung cancer. The EBC-1 line was established from a metastatic skin tumor of a patient with squamous cell carcinoma of the lung. The cells grew in a monolayered sheet with a population-doubling time of 42 hr. The chromosome number showed wide variation from 35 to 102 with a modal peak at 53. The ABC-1 line was established from pleural effusion of a patient with adenocarcinoma of the lung. The cells grew mainly in a floating clump with a population-doubling time of 72 hr. Karyotypic analysis disclosed a wide variation from 25 to 57 with two modal peaks at 53 and 54. The EBC-1 and ABC-1 lines may be useful for biological, cytopharmacological and therapeutic studies of human squamous cell carcinoma and adenocarcinoma of the lung.
Keywords
human lung cancer cell line
squamous cell carcinoma
adenocarcinoma
tissue culture
ISSN
0030-1558
NCID
AN00032489