Journal of Okayama Medical Association
Published by Okayama Medical Association

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好塩基球の反応性に関する研究 第1編 塗沫標本による好塩基球の反応性の検討

Goda, Yoshinori
97_429.pdf 7.2 MB
Abstract
Morphological changes of basophils stimulated by anti-IgE and anti-IgG were observed in 73 asthmatic and 10 healthy subjects by smear specimen. Basophil reactivity to both anti-IgE and anti-IgG was low in the healthy subjects. Basophils from atopic asthmatics reacted to anti-IgE more strongly than the cells from the healthy subjects, while the basophil response to anti-IgG was low. Basophil reactivity of intractable asthmatics to anti-IgG was higher than the reactivity to anti-IgE. Basophils from asthmatic subjects with a high serum IgE level reacted to anti-IgE strongly, while the cells from subjects with a low serum IgE level (less than 100IU/ml) showed a high response to anti-IgG. In the cases with a basophil ratio of less than 0.5, basophils released a large amout of histamine by stimulation with anti-IgE. The release of histamine induced by anti-IgE was low in the cases with low reactive basophils. These results suggest that observation of morphological changes of basophils stimulated by anti-IgE and anti-IgG is useful for the clinical study of bronchial asthma.
Keywords
好塩基球の反応性
抗ヒトIgE
抗ヒトIgG
気管支喘息
ISSN
0030-1558
NCID
AN00032489