Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

全身性エリテマトーデスの免疫異常とその成因に関する研究 第2編 サプレッサーT細胞機能に関する研究

Nakamura, Zenichi
Thumnail 93_203.pdf 757 KB
Abstract
Peripheral mononuclear cells from patients with systemic lupus erythematosus(SLE), when incubated for 48hr with or without concanavalinA(ConA), were found to be capable of inhibiting the pokeweed mitogen(PWM)-induced polyclonal immunoglobulin(Ig) secretion of cells from normal individuals. Furthermore, anti-T cell antibody in sera from patients with SLE could not preferentially kill the precursor cells of ConA-induced suppressor cells. However, in SLE these suppressor cells did not significantly affect the Ig secretion of autologous B cells. These results suggest that defective suppressive activity in patients with SLE does not occur at the T cell level, but that it is most likely due too the defect of B cells in recognizing suppressive information from suppressor T cells, which is caused by in vivo polyclonal B cell activation.
Keywords
suppressor T cell function
PWM-induced Ig secretion
polyclonal B cell activation
systemic lupus erythematosus
ISSN
0030-1558
NCID
AN00032489