Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

全身性エリテマトーデスの免疫異常とその成因に関する研究 第2編 サプレッサーT細胞機能に関する研究

Nakamura, Zenichi
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Peripheral mononuclear cells from patients with systemic lupus erythematosus(SLE), when incubated for 48hr with or without concanavalinA(ConA), were found to be capable of inhibiting the pokeweed mitogen(PWM)-induced polyclonal immunoglobulin(Ig) secretion of cells from normal individuals. Furthermore, anti-T cell antibody in sera from patients with SLE could not preferentially kill the precursor cells of ConA-induced suppressor cells. However, in SLE these suppressor cells did not significantly affect the Ig secretion of autologous B cells. These results suggest that defective suppressive activity in patients with SLE does not occur at the T cell level, but that it is most likely due too the defect of B cells in recognizing suppressive information from suppressor T cells, which is caused by in vivo polyclonal B cell activation.
suppressor T cell function
PWM-induced Ig secretion
polyclonal B cell activation
systemic lupus erythematosus