A human B-cell line designated as BALL-1 was established from the peripheral blood of a patient with acute lymphoblastic leukemia (ALL). Neither Epstein-Barr virus (EBV) nor its genome was detectable. The morphological and growth characteristics were clearly distinct from those of numerous EBV-positive lymphoblastoid cell lines previously reported. BALL-1 cells probably originated from the donor's leukemic cells judging from their cytogenetic, morphological and surface features. This BALL-1 line is the first EBV-negative B-cell line established from ALL.
human acute lymphoblastic leukemia
leukemic B-cell line