Changes of the cerebro-spinal fluid space elastic compliance after cardiac arrest and resuscitation in dogs (Ⅱ) Effect of barbiturate therapy

To corroborate barbiturate protection from cerebral anoxia after cardiopulmonary arrest, barbiturate therapy was done on 12 adult dogs. Induction of cardiac arrest, cardiopulmonary resuscitation and the measurement of the CSFS-EC, cerebro-spinal fluid space elastic compliance, were done as the same as reported in part one. Values of the arrested group of part one were used as control. Pentobarbital sodium was given intravenously after the reestablishment of the circulation. Twelve animals were devided into two groups, 7 mg/kg and 15 mg/kg of pentobarbital were given to each of 6 animals. Each group of animals were devided into two, again, regarding from the resuscitation time (short ≦ 6 minutes, long ≧ 7 minutes), S-7, S-15, L-7 and L-15 respectively. CSFS-EC of the L-15 increased dramatically at 30 minutes and came down to the control value at one hour. The change of CSFS-EC at 30 minutes of the L-7 was not significantly different from the control. At one hour, CSFS-EC of L-15, L-7 and control were not significantly different from each other. Although CSFS-EC of the control decreased gradually for next 23 hours, L-15, L-7 stayed without significant changes. CSFS-EC of S-15 and S-7 decreased significantly 2 and 4 hours, and returned to the same value as the control group. Barbiturate therapy exaggerate the changes of CSFS-EC and delayed the recovery of the central nervous system from the effect of whole body ischemia and it was hard to find out any reason to do barbiturate therapy after cardiac arrest.