Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.


Shibata, Shiro
Takeda, Tsuneo
Kajihara, Masayuki
Saito, Ryusuke
Endo, Yoichi
Ogura, Yoshio
90_1105.pdf 786 KB
Aleviatin (Diphenylhydantoin) is well known as an excellent antiepileptic drug, especially against grand-mal convulsion. Side reaction of this drug, however, was various and the reports concerning side reaction were many. The authors have reported two patients of Aleviatin intoxication with the complaint of postural disturbance. Some discussions and comments were made on the cases and literatures. Summarizing the symptoms of these side reactions, 1. acute intoxication a. skin manifestations: rash like scarlet fever or urticaria, exfoliative dermatitis, systemic lupus erythematoid eruption, Stevens-Johnson syndrome b. neurological signs: postural disturbance, ataxia, tremor, dysarthria, diplopia, nystagmus, tinnitus, hearing impairment, choreoathetoid movement c. psychological signs: nervousness, excitement, disorientation, insomnia, pseudodementia d. blood manifestation: leucopenia, anemia, leukemoid change e. digestive disorders: thirst, nausea, vomiting, constipation 2. chronic intoxication a. gum hypertrophy b. hypertrichosis c. hyperglycemia