Effects of toxohormone on cancer immunity

Toxohormone (T.H.) was made to react with the series of tumor immunity in experimental animals and the following results were obtained. 1. T.H. was found to inhibit the anit-tumor activity of regional lymphnode cells in the Ehrlich cancer bearing mice in vitro. 2. T.H. proved to diminish the inhibitory activity of regional lymphnode cells on tumor proliferation in the neutralization-tumor transplantation tests in vitro. 3. T.H. showed an inhibitory activity on immune lymphocytes in the direct method of the macrophage migration tests in vitro. However, by the indirect method, it did not show such activity. This seems to be due to the fact that T.H. acts directly on lymphocytes but not on the inhibitory factor of macrophage migration. T.H. may be a factor suppressing cancer immunity in advanced cancer cases nonspecifically.