Isometric handgrip exercise were performed to evaluate the left ventricular performances in fifteen normal adults by echocardiography. The following parameters increased significantly during isometric handgrip exercise. blood pressure, heart rate, cardiac index, stroke work index, contractile index. The normal hearts responded to the increase of afterload during isometric exercise by increased heart rate but the promotion of contractile state was not seen, so it was thought that the wall stress or the wall thickness increased.