Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

環境汚染物質(重金属など)の生体膜に対する作用 第2報 各種有機水銀の生体膜に対する作用,特にK(+)区画性に対して

Hasegawa, Tohoru
89_1495.pdf 237 KB
The effects of organic mercury compounds on the biomembrane were studied with specific reference to the K(+) compartment and the following results were obtained. 1) PhMC, PhMA, and MMC had effects of decoupling action on the oxidative phosphorylation, and PCMB inhibited the ADP-stimulated respiration, and mercury chloride inhibited the respiration. 2) On the red blood cell and mitochondrial membrane, these organic mercury compounds induced the K(+) release in the order of HgCl(2) PhMC PhMA MMC PCMB. 4) It is suggested that the liophilic nature of organic mercury compounds plays an important role in the reaction of K(+) release.