Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

ラット臓器の脂質過酸化反応におよぼす放射線照射の影響 第3編 放射線照射ラツト各臓器の脂質過酸化物形成能に及ぼす放射線防護物質投与(in vivo)の影響について

Watanabe, Setsuo
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Effects of tathione and cepharanthin, the radiation-protective agents, on the lipid peroxidation in rat organs were studied, and obtained the results as follows. (1) The acceleration of lipid peroxide formation induced by X-irradiation can be inhibited by the administration of tathione prior to the irradiation and by the dose administered. Such an inhibitory effect is especially marked in the liver, and as reported in Part Ⅰ and Part Ⅱ, in view of correlations among X-irradiation effect, lipid peroxidation and fatty acid composition in the liver, it seems that glutathione in vivo is somehow involved in the acceleration of lipid peroxidation. (2) The increase of lipid content observable in the liver of X-irradiated animal could not be observed in the animals administered with tathione. (3) Cepharanthin showed not any relation to the lipid peroxidation.