Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

キノリン誘導体の骨髄造血機能に及ぼす影響に関する研究 第1編 骨髄臨床組織培養法による白血球系造血機能に及ぼすクロロキンの影響

Hayashi, Nobuhiro
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In order to observe the influences of chloroquine on the bone marrow leukopoiesis, clinical tissue culture of bone marrow from normal rabbits was conducted. Chloroquine diphosphate solutions at various concentrations were added directly to the culture media and observations were carried out on the outgrowth, cell density, wandering velosity of neutrophils, carbon-particle phagocytosis and vital staining. As a result, it has been demonstrated that the leukopoietic functions of bone marrow were hardly inhibited in the medium containning 2γ/dl and 20γ/dl of chloroquine, but were markedly inhibited in the medium containning 200γ/dl and 2000γ/dl of chloroquine.