Journal of Okayama Medical Association
Published by Okayama Medical Association

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ウラン体内投与,放射線外部照射ならびにその二重負荷に関する実験的研究 第2編 二重負荷に対するCa-EDTA, Cysteineの防護効果について

Fujii, Yoshio
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Abstract
In order to investigate the effectiveness of the chemical protective agents against mice and rabbits doubly stressed by uranium administration and gamma irradiation as reported in Study 1, Ca-EDTA and Cysteine were used as the agent. For mice irradiated 650r gamma ray on whole body after 10mgU/kg intraperitoneal injection of uranyl nitrate, Cysteine (100mg/kg, 200mg/kg, 400mg/kg, respectively) was intraperitoneally injected 10-15min. before the treatment, or Ca-EDTA of the same above doses after 2hr. The double effect of Cysteine and Ca-EDTA was examined also. For rabbits irradiated 800r gamma ray on whole body after 0.2mgU/kg intravenous injection of uranyl nitrate, Cysteine 50mg/kg were intravenously injected 10-15min. before the treatment, or Ca-EDTA 50mg/kg after 2hr. The double effect of Cysteine and Ca-EDTA was examined also. On mortality rate, and kidney histology of mice, none protein nitrogen of blood of rabbits, Ca-EDTA was effective while Cysteine was uot showed any recognizable effect, nor the combination of Ca-EDTA and Cysteine, too.
Note
学位番号 甲第196号
ISSN
0030-1558
NCID
AN00032489