Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

マウス白血病の発生機構に関する実験的研究 第2編 X線照射によるRF系マウス白血病の発生に及ぼす胸腺及び脾摘出の影響

Kunisada, Mineo
Thumnail 77_1169.pdf 278 KB
With the object to elucidate the role played by thymus and spleen in radiation leukemogenesis, effects of thymectomy and splenectomy on the induction of leukemia in RF mice by X-ray-irradiation were studied, dividing lymphocytic leukemia into thymic type and non-thymic type. As the result it has been clarified that thymectomy mainly inhibits the occurrence of the thymic type lymphocytic leukemia while splenectomy on the occurrence of the non-thymic type lymphocytic leukemia. As for the mechanism of this inhibition, a discussion was made on the significance of thymus and spleen as the organs that are constituted of the cells most susceptible to neoplastic transformation. After both thymectomy and splenectomy not a single mouse developed leukemia when exposed to X-ray-irradiation.