Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

海猽遊離腸管の被働性過敏症に関する研究 第3篇 抗原及び諸種薬物の除感作作用,及びBenadrylの抑制作用

Nasu, Shozo
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At the experiment of the passive intestine Schulz-Dale reaction in guinea pig, the actions of antigen, histamine and acetylcholine were compared each other on the desensitization and suppression by benadryl. The results are as follows: 1). Desensitization is established by antigen but not by acetylcholine. It seems that desensitization sometime is established by histamine. 2). Suppressive action by benadryl in its critical concentration shows that antigen is nearer to histamine than acetylcholine. 3). Benadryl concentration in order to abate contracted intestine is the same as in the case of contraction by antigen and histamine but needs higher concentration for the contraction by acetylcholine.