In the sutdy on the relationship between the so-called auto-liver antibody that acts against the liver tissue antigen and the serum protein picture, mainly in the cases of infectious hepatitis, the author arrived at the following conclusions. 1. The total serum protein in the case positive to the so-called auto-liver-antibody is a little lower than that in the case negative to this antibody. 2. In the case postive to auto-liver-antibody, γ-globulin is markedly increased in volume as compared with the case negative to the antibody. 3. As for the changes in the serum protein fractions, when auto-liver-antibody titer is at peak in the clinical course, albumin, α-and β-globulins rather tend to decrease as compared with these before or after such a peak period, while γ-globulin shows a slight increase. However, along with a fall or disappearance of this antibody titer γ-globulin shows a decreasing tendency. From these results it can be assumed that there is a close relationship between the mechanism increasing the content of γ-globulin and the mechanism producing auto-liver-autibody in hepatitis, especially in infectious hepatitis and liver cirrhosis.