Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

抗骨髄血清による実験的貧血に関する研究 第4編 骨髄組織培養に於ける巨核球機能に就いて

Sakakibara, Hideo
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The author calculated the number of platelets in the peripheral blood of the guinea pigs given the intraperitoneal injection of bone-marrow anti-serum and determined the fuction of megakaryocytes by performing the tissue culture of the bone marrow from these test animals. The following are the results of the present experiment: 1. By the intraperitoneal injection of the bone-marrow antiserum the number of platelets in the peripheral blood of the test guinea pigs decreases beyond the physiologically normal limit. 2. The intraperitoneal injection of the anti-serum of bone marrow brings about a decrease in the number of megakaryocyte appearance in the bone marrow culture of the test animals as well as the diminution of megakaryocyte function, especially the decrease in the number of megakaryocytes carrying on the separation of platelets by projecting tentacles, and it is believed that this phenomenon is chiefly responsible for the decrease of platelet number in the peripheral blood.