Latent cerebral local anaphylaxis (LCLA) has been experimentally probed to be an epileptic disposition and a state of arrangement of convulsion by many reports. The author measured the hexokinase activity in the cerebral cortex of rabbits with latent cerebral local anaphylaxis which was experimentally influenced by the use of glutamic acid, glutamine, aspartic acid, asparagine, γ-aminobutyric acid and α-ketoglutaric acid and the following results were obtained. 1) The hexokinase activity in the cerebral cortex of rabbits with LCLA is decreased, compared with that of normal rabbits. 2) Asparagine markedly accelerates the activity, while γ-aminobutyric acid does slightly. 3) Glutamic acid, glutamine or aspartic acid has almost no influence on the activity. 4) α-Ketoglutaric acid shows a marked inhibition to the activity as seen in normal rabbits.