Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

肝組織鉄の組織化学的研究 第1編 肝疾患時,肝組織鉄の組織化学的研究

Kusudo, Hiroshi
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The distribution of liver tissue iron was histochemically observed on the cutting section of liver tissue diseases, especially acute hepatitis, chronic hepatitis, subacute liveratrophy, livercirrhosis and posthepatic syndrome, and the correlation of it with the pathohistological findings of the same cutting section and liver function, serum bilirubin value and serum iron etc. in the same patient was studied at the same time. And the results were as follows. 1. The Prussian blue method, Turnbull blue method and removed surface method, as the detective method of liver tissue iron, and the possibility of the error by the detective method were observed. And the reliable condition was decided. 2. The iron detected in the liver tissue of liver diseases was triatomic iron, but diatomic iron was not observed. And the detection of iron before and after the removed surface was obtained in the same dosis at the same place. 3. In acute hepatitis, the increase of iron was mostly seen in the liver cells of lobular central zone and intermediate zone and it was next in the sinus and stellate cell, and the distribution of iron in the Glisson's sack was very few. But the increase of it in the Glisson's sack was observed on the cases with the inflammation of Glisson's sack. 4. In subacute liveratrophy, the deposited dosis of iron was remarkable and it's distribution was remarkable in the liver parenchymal cells of intermediate zone and marginal zone. 5. In chronic hepatitis, the iron dosis of liver tissue was generally increased and the distribution of the iron deposit was decreased, on the contrary, in the central zone and the increase of it was seen in the intermediate zone, marginal zone and Glisson's sack. In the cases with the inflammatory findings of Glisson's sack, the increase of iron deposition was observed. 6. In livercirrhosis, there were the cases with the increase of iron and the cases without the increase of iron and it's distribution was remarkable in the circumference liver lobulus, especially the Glisson's sack. 7. In posthepatitic syndrome, there were the cases with considerable increase of iron and the cases without increase of iron and it's deposition was remarkble in the intermediate zone, especially the marginal zone, but no increasing tendency of iron deposition was found in the Glisson's sack. 8. The above iron deposition of liver tissue was mostly found in the degenerative cells in which the nucleus was not markedly attacked from the degeneration. 9. The liver tissue iron of these diseases was due to the hemosiderin produced from the erythrocyte flowing out to blood vessel with the pathologic changes of the liver and the liver cells without the pathologic change of the nucleus, in the region with the remarkable pathologic change participated in it.