Journal of Okayama Medical Association
Published by Okayama Medical Association

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Clearance法による腎機能に関する研究 第2編 実験的肝障碍時における腎機能の消長

Oka, Tetsuo
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Abstract
The kidney function in the administration of various liver poisons was observed by means of kidney clearance method. And the results were as follows. 1. In the cases with the subcutaneous injection of formic acid allyl 50 mg per kg of one time, Ht, GFR and RPF were all risen at the 2 nd hour after the injection, especially RPF was remarkable, and it was rapidly fallen and the cases was deceased. FF declined and RR did not show a fixed tendency. 2. In the cases with the continuous subcutaneous injection of formic acid allyl 10 mg per kg every day, Ht showed the risiug tendency, RPF showed the rise at the 1-3 rd day after the injection and showed the high value, GFR declined at the 1 st day and rose at the 2 nd day and it showed high value, and FF and RR did not show a fixed tendency. 3. In the cases with the peroral administration of phosphorus yellow 0.02 g per kg, Ht temporarily rised at the 4-6 th hour, GFR and RPF rose at the 2-4 th hour, especially the high value of RPF was observed. FF generally showed the rise at the 2 nd hour and it showed the decrease after 2 hours. RR showed the temporary increase in 3 of 5 cases. 4. In the cases of the peroral administration of carbon tetrachioride 0.5 cc per kg of one time, Ht generally rose at the 4-6 th hour, GFR and RPF showed the high value in 3 of 5 cases at the 4-6 th hour and it gradually fell with the considerable shaking. FF and RR did not show the fixed tendency. 5. In the cases of the continucus subcutaneous injection of carbon tetrachloride 0.3 cc per kg for 3 days, GFR and RPF showed the rise since the next day, and FF showed the decrease in the living cases and it showed the rise immediately before the death. RR did not show a fixed tendency. 6. In the cases with the subcutaneous injection of chloroform (in the dilution of 20%) 0.5 cc per kg, GFR and RPF rose at the 2-4-6 the hour and it fell at the 24 th hour or 2nd day and showed low value. 7. In the cases with the intravenous injection of hepatotoxin (0.5 cc per kg) of antibody titer 64, GFR and RPF showed the temporary rise, and FF and RR did not show the fixed tendency. 8. In the cases with the intrevenous injection of hepatotoxin (0.25 cc per kg) of antibody titer 256 ofr 3 days, GFR and RPF fell and decreased at the 2-7 th day, those showed the reconvery and rise at the 10 th day more than those before the administration, FF showed a little decreasing tendency and RR did not show the fixed tendency. 9. The kidney function in liver damage often showed the compennation temporarily, especially it was remarkable on GFR and RPF, but no fixed tendency was scarecely observed on FF and RR as individal function. But the compeneative function was not observed and the decline was observed on the cases with the continuous administration of hepatotoxin of high antibody titer for 3 days, and the complicated correlation between liver function and kidney function was observed.
ISSN
0030-1558
NCID
AN00032489