Journal of Okayama Medical Association
Published by Okayama Medical Association

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肝炎に関する血清学的研究 第1編 沈降反応による流行性肝炎における肝自己抗体の検討

Itano, Toshio
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Abstract
The auther made the precipitation test using the extracted solution of human liver with physiological salt solution as the antigen. And the results were as follows. 1. In cases of acute hepatitis, the antibody to the extracted antigen from human liver with physiological salt solution was identified by the precipitation test and it showed rather high positive rate than that of other diseases. 2. The close correlation among the appearance of it's antibody in precipitation test, the damaged grade of liver function and the damaged grade of pigment excreting function was observed. 3. The close correlation between the appearance of it's antibody in peripheral blood stream by precipitation test and the value of serum bilirubin was observed. 4. The correlation between the apperance of it's antibody in peripheral blood stream by the precipitation test and hepatomegalia was observed. 5. The close correlation between the appearance of it's antibody in peripheral blood stream by the precipitation test and the number of leupocyte was not observed, but the decreasing tendency of leukocyte count was observed on the appearance of it's antibody in peripheral blood stream, and lymphocytosis, monocytosis and the appearance of plasmoid cells were also observed on the percentage of leukocyte, in the cases with the the observation of clinical course. 6. The appearance of it's antibody in peripheral blood stream by the precipitation test was considerably well observed on the begin of disease and it disappeared from the blood stream with the convalescence of disease, but it was identified at the time of relapse and recurrence in chronic cases. 7. In epidmic hepatitis, the substance corresponding to the extracted antigen from the human liver was identified by the precipitation test, other than the complement fixation test, and the presence of both antibodies corresponding to the same antigen was clarified. And the both antibodies showed almost same vicissitude with the clinical course and it was clarified that they were the auto-liver antibody produced in the living body as the antigen, the substance produced from the primary liver damage by virus of hepatitis (i.e. the products by the degeneration, necrosis and distruction in liver).
ISSN
0030-1558
NCID
AN00032489