Journal of Okayama Medical Association
Published by Okayama Medical Association

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肺結核患者の焦性ブドー酸代謝 第2編 肺結核患者における尿中焦性ブドー酸の消長に及ぼす各種ビタミンの影響

Nakanishi, Yoji
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Abstract
The influence of glucose and various vitamin to the excreted dosis of pyro-racemic acid in urine was observed on 40 cases (male 19, female 21) of lung tuberculosis. And the results were as follows. 1. The dosis of vitamin B(1) and B(2) in urine for one day had relation to the severity of disease and the excreted dosis of visamin B(1) and B(2) into urine decreased with severe case. 2. The decrease of the excreted dosis of pyro-racemic acid in urine was observed on the 30 cases of 40 cases with the intravenous injection of 20% glucose 0.1 cc per kg and it was observed on the 20 cases of 40 cases with the administration of 20% glucose 0.2 cc per kg. In other words, glucose activated the disposal function of Pyro-racemic acid in some degree. And at that time, the considerable correlation between the severity of disease and the above function was observed, but it had no relation with cavity, excretion of bacillus, erythrocyte sedimentation rate liver function or subjective symptoms. 3. Giving vitamin B(1) 5 mg at 1 hour before the administration of 20% glucose 0.2 cc per kg, the decrease of pyroracemic acid was observed on the 6 cases of 20 cases which did not show the decrease or pyro-racemic acid, and it was shown in the 4 more cases on the use of cocarboxylase 5 mg instead of vitamin B(1). Furthermore, it was seen in the 4 cases of 10 cases, which did not show the decrease of pyro-racemic acid on the use of cocarboxylase, on the mixed use of cocarboxylase and vitamin B(2) 5 mg and it was seen in the 6 cases of them on the use of cocarboxylase and glucose after the adminstration of pantotenic acid calcium 200 mg for 3 day. The above cases included the 4 cases showing the decrease on the mixed use of vitamin B2. And it was seen in the 6 cases of them on the administration of thioctic acid 10 mg at 1 hour the administration of glucose, and the 3 cases of them were same to the cases showing the decrease on the mixed use of cocarboxylase and pantotenic acid and other 3 cases was the cases which did not show the decrease on the mixed use of the above drugs. And the decrease of pyro-racemic acid was seen in all of 10 cases on the mixed use of thioctic acid 10 mg and glucose. 4. The disposition of pyroracemic acid became smooth by the addition of cocarboxylase, pantotenic acid and thioctic acid etc. with the combination of phosphorus in vitamin B1 in lung tubercuosis. In other words, the latent deficiency of vitamin and enzyme, especially the deficiency of thioctic acid, was noticed.
ISSN
0030-1558
NCID
AN00032489