Journal of Okayama Medical Association
Published by Okayama Medical Association

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再生不良性貧血に於ける鉄・銅代謝に関する研究 第三編 放射性鉄による患者血清中の毒性因子(催貧血性物質)が家兎の臓器Non-hemin鉄に及ぼす影響に関する研究

Date, Yoshihiro
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Abstract
After the intravenous injection of the radioactive iron to the rabbits previously administered with the serum of patient with hypoplastic anemia, the radioactivity and the specific radioactivity on each fraction of the visceral non-hemin iron were evaluated. The results are as follows: 1. When the radioactive iron is injected intravenously, it is quite readily mobilized, without being mixed with the indigenous depot iron existing in the viscera. 2. The rate of metabolism in such fractions is most rapid in the fraction Ⅲ, followed by fractions Ⅱ and Ⅰ, in that order; but the metabolism in fraction Ⅳ shows no fixed trend. 3. It has been confirmed that there exist in the serum of the patient with hypoplastic anemia factors disturbing the hematopoietic functions of the rabbit bone marrow. 4. The surplus iron not mobilized is stored is stored in viscera in the same order as mentioned above, namely, first in fraction Ⅲ followed by fractions Ⅱ and Ⅰ.
ISSN
0030-1558
NCID
AN00032489