Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.


Mitsui, Hideo
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The author estimated by Warburg's manometer, the tissue metabolism of normal (10 cases) and carcinomatus (73 cases) patients who were hospitalized in Okayama University Hospital. The influence of Roentgenrays on cancer tissue was also studied after irradiating (900r, 1800r 2700r and 3600r each) on them, and the relation between its clinical or histological findings and cancer tissue metabolism rate or metabolic X-ray sensitivity. Following results were obtained: 1) Tissue metabolism of the normal cervix is relatively high in the respiration rate, but low in the glycolytic action. 2) Tissue metabolism of non-treated uterine cancer is slightly higher in the respiration rate and notably higher in the glycolysis, comparing to those of the normal uterine tissue. 3) Influence of X-rays on the cancer tissue metabolism: the respiration rate is markedly suppressed and becomes lower than that of the normal tissue by the irradiation described above, and the glycolytic action is not suppressed by the irradiation of 900 r, but is suppres sed, not less than the rate of the normal tissue, by irradiation of over 1800 r. 4) Relation between the non-treated cancer tissue metabolisn and its clinial and histological findigs. The metabolism rates increase in following cases; advanced cases classified clinically, I type in Nagase's classification, cases after menopause and large -tumor-bearing group. 5) Relation between the metabolic X-ray sensitivity and the clinical and histological findings: In creases of X-ray sensitivity are observed in following cases; younger age group, Ⅳ-Ⅵ type in Mandelstamm's method, cases schowing intersive changes in the tissue and increasing T.P.T-positive cells, and spinous-cell group in Martzloff's classification. 6) Metabolism suppressing rate, i.e. metabolic X-ray sensitivity is closely related to the histomorphological findings, and is thought to be one of the important methods to determine the X-ray sensitivity.