Cow sera were given into ear veins of rabbits and marmots by 2 cc per kg three times in every other days. Three weeks after sensitization cow sera were given by 2 cc in similar way, while their carotic blood pressure was measuring simultaneously. Ravonal and Anergen restrained remarkbaly not only descending of blood pressure, but inhibited other ill effects too. Active and passive anaphylaxis were examined in marmots. In contrast group they died by 100% and in those used Ravonal by 45.8% and in those used Anergen by 25%. The pathologic and histologic figures of Ravonal and Anergen groups were also silightly im comparing with that of contrast group.