EXPERIMENTAL AND CLINICAL STUDIES ON PARATHION-POISONING1st Chapter Studies on Blood Cholinesterase and Clinical Symptoms of Parathion Poisoning

Of late, parathion has come to be used as a priventives, to annihilate larva of pearl moth; there happened occasionally, as well known, cases of poisoning due to this use. With some experiments in which parathion emulsion (ethyl-parathion 46.6~47.0%) was given to a rabbit, as well as consulted human cases in which such a great number of it has been staged as to amount even to 43, which were selected out of parathion sprayers and factory workers, containing 20 mild cases, 11 moderate cases and 12 serious cases, probably maximum number ever treated, the blood cholinesterase activity was measured due to Ammon's method thus examining with its clinical symptoms, and arrived at such results al follows: 1. In case poisoned by parathion, blood cholinesterase activity apt to show a marked descent. Considering both cholinesterase function as well as certain clinical symptoms, the actual state of this disease is ascribed to lie in the inhibition of cholinesterase activity. 2. The inhibition of blood cholinesterase may be introduced as a very unique aspect and significant feature encountered in our diagnose. 3. The primary rate of cholinesterase inhibition and the seriousness of disease go parallel. 4. In dividing the degree of seriousness shown by patients into latent poisoning, mild one, moderate, as well as serious, their blood cholinesterase activities are proved respectively; 100~50%, 5~20%, 20~10%, and below 10%. 5. Classifying those clinical symptoms shown by patients into several stages, may contribute somewhat to the benefit in their treatment.